The COP9 signalosome

被引:385
作者
Wei, N [1 ]
Deng, XW [1 ]
机构
[1] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA
关键词
CSN; Jab1; SCF; Nedd8/Rub1; protein degradation; ubiquitin-proteasome pathway;
D O I
10.1146/annurev.cellbio.19.111301.112449
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The COP9 signalosome (CSN) is composed of eight distinct subunits and is highly homologous to the lid sub-complex of the 26S proteasome. CSN was initially defined as a repressor of photomorphogenesis in Arabidopsis, and it has now been found to participate in diverse cellular and developmental processes in various eukaryotic organisms. Recently, CSN was revealed to have a metalloprotease activity centered in the CSN5/Jab1 subunit, which removes the post-translational modification of a ubiquitin-like protein, Nedd8/Rub1, from the cullin component of SCF ubiquitin E3 ligase (i.e., de-neddylation). In addition, CSN is associated with de-ubiquitination activity and protein kinase activities capable of phosphorylating important signaling regulators. The involvement of CSN in a number of cellular and developmental processes has been attributed to its control over ubiquitin-proteasome-mediated protein degradation.
引用
收藏
页码:261 / 286
页数:28
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