Nitric oxide in the regulation of body temperature and fever

被引：46

作者：

Steiner, AA

Branco, LGS ^{[1
]}

机构：

[1] Univ Sao Paulo, Dent Sch Ribeirao Preto, BR-14040904 Ribeirao Preto, SP, Brazil

[2] Univ Sao Paulo, Fac Med Ribeirao Preto, BR-14040904 Ribeirao Preto, SP, Brazil

来源：

JOURNAL OF THERMAL BIOLOGY | 2001年 / 26卷 / 4-5期

基金：

巴西圣保罗研究基金会;

关键词：

nitric oxide; nitric oxide synthase; body temperature; thermoregulation; fever; central nervous system; set point; acute phase reaction;

D O I：

10.1016/S0306-4565(01)00038-9

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

(1) In this article, the aspects regarding the role of nitric oxide (NO) in thermoregulation and fever is reviewed. (2) It is currently believed that fever results from dc novo synthesis of cytokines and subsequent stimulation of the generation of prostaglandins in the central nervous system. However, the mechanisms underlying fever still remain only partly understood. (3) Recently, a new biologically active molecule has been described, i.e., the gaseous Compound NO. This molecule started a revolution in the understanding of several physiological and pathophysiological processes, including thermoregulation and fever. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：325 / 330

页数：6

共 36 条

[1] Prostaglandin E2 enters the brain following stimulation of the acute phase immune response [J].