A colorimetric titration method for quantification of millimolar glucose in a pH 7.4 aqueous phosphate buffer

被引：27

作者：

Boduroglu, S ^{[1
]}

El Khoury, JM ^{[1
]}

Reddy, DV ^{[1
]}

Rinaldi, PL ^{[1
]}

Hu, J ^{[1
]}

机构：

[1] Univ Akron, Dept Chem, Akron, OH 44325 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 17期

关键词：

arylboronic acid; sugar sensing; dynamic covalent complexation; colorimetric;

D O I：

10.1016/j.bmcl.2005.05.075

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

3-Pyridinylboronic acid is identified as a key sensing element for reversible sugar complexation in an aqueous solution at the physiological pH. The utility of a sensing element has been demonstrated through a simple colorimetric titration of glucose using absorption spectroscopy in the visible region. The mechanism of the high diol/triol binding affinity of pyridine boronic acid in the neutral pH is discussed based on the H-1 and B-11 NMR spectroscopic studies. (c) 2005 Elsevier Ltd. All rights reserved.

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页码：3974 / 3977

页数：4

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