Naturally arising CD25+CD4+ regulatory T cells in tumor immunity

被引：72

作者：

Nomura, T ^{[1
]}

Sakaguchi, S ^{[1
]}

机构：

[1] Kyoto Univ, Inst Frontier Med Sci, Dept Expt Pathol, Sakyo Ku, Kyoto 6068507, Japan

来源：

CD4-PLUSCD25-PLUS REGULATORY T CELLS: ORIGIN, FUNCTION AND THERAPEUTIC POTENTIAL | 2005年 / 293卷

关键词：

D O I：

10.1007/3-540-27702-1_13

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Naturally arising regulatory T (T-R) cells, represented by CD25(+)CD4(+) T-R cells, play an essential role in maintaining immunological self-tolerance. This T cell-mediated dominant control of the immune response not only inhibits the development of autoimmune disease, but also impedes effective immuno surveillance against autologous tumor cells. Attenuation of T-R cell-mediated immune suppression can therefore evoke effective tumor immunity in otherwise nonresponsive animals. This common regulatory mechanism for autoimmunity and tumor immunity can be exploited when devising a novel immunotherapy for cancer.

引用

页码：287 / 302

页数：16

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