Expression analysis and chromosomal assignment of PRA1 and RILP genes

被引：13

作者：

Bucci, C

De Gregorio, L

Bruni, CB

机构：

[1] Univ Lecce, Dipartimento Sci & Tecnol Biol & Ambientali, I-73100 Lecce, Italy

[2] Ist Nazl Tumori, Div Expt Oncol A, I-20133 Milan, Italy

[3] Univ Naples Federico II, Dipartimento Biol & Patol Cellulare & Mol L Calif, I-80131 Naples, Italy

[4] Univ Naples Federico II, CNR, Ctr Endocrinol & Oncol Sperimentale, I-80131 Naples, Italy

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2001年 / 286卷 / 04期

关键词：

Rab proteins; GTPases; endocytosis; PRA1; RILP; chromosomal mapping;

D O I：

10.1006/bbrc.2001.5466

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

PRA1 (prenylated Rab acceptor) is a general regulator of Rab proteins, while RILP (Rab interacting lysosomal protein) is a specific effector for Rab7. It has been shown that PRA1 interacts with Rab proteins and with VAMP2. Therefore PRA1 is probably an important factor for membrane traffic, linking together the function of Rab proteins and SNAREs. RILP has a key role in the control of transport to degradative compartments together with Rab7 and probably links Rab7 function to the cytoskeleton. Here we have studied by Northern blot the expression of the two genes in several different human tissues. The 0.8-kb mRNA for human PRA1 is ubiquitously expressed, while the two mRNAs for RILP are differentially expressed. In addition, we have assigned the human PRA1 gene to chromosome 19q13.13-q13.2 and the human RILP gene to chromosome 17p13.3. (C) 2001 Academic Press.

引用

页码：815 / 819

页数：5

共 19 条

[1] Rab7: A key to lysosome biogenesis [J].