The management of portal hypertension: Rational basis, available treatments and future options

被引：213

作者：

Bosch, Jaime ^{[1
]}

Berzigotti, Annalisa ^{[1
,2
]}

Garcia-Pagan, Juan Carlos ^{[1
]}

Abraldes, Juan G. ^{[1
]}

机构：

[1] Univ Barcelona, Hosp Clin, IDIBAPS, Liver Unit,Hepat Hemodynam Lab, E-08036 Barcelona, Spain

[2] Hosp Clin Barcelona, Ctr Diagnost Imatge, Barcelona, Spain

来源：

JOURNAL OF HEPATOLOGY | 2008年 / 48卷

关键词：

portal pressure; hepatic vascular resistance; nitric oxide; oesophageal/gastric varices; portal hypertensive gastropathy; variceal bleeding; HVPG; non-selective beta-blockers; endoscopic band ligation; TIPS;

D O I：

10.1016/j.jhep.2008.01.021

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Variceal bleeding is the last step in a chain of events initiated by an increase in portal pressure, followed by the development and progressive dilation of varices until these finally rupture and bleed. This sequence of events might be prevented - and reversed - by achieving a sufficient decrease in portal pressure. A different approach is the use of local endoscopic treatments at the varices. This article reviews the rationale for the management of patients with cirrhosis and portal hypertension, the current recommendations for the prevention and treatment of variceal bleeding, and outlines the unsolved issues and the perspectives for the future opened by new research developments. (c) 2008 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

引用

页码：S68 / S92

页数：25

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