Not always the bad guys: B cells as regulators of autoimmune pathology

被引：221

作者：

Fillatreau, Simon ^{[3
]}

Gray, David ^{[1
]}

Anderton, Stephen M. ^{[1
,2
]}

机构：

[1] Univ Edinburgh, Inst Immunol & Infect Res, Sch Biol Sci, Edinburgh EH9 3JT, Midlothian, Scotland

[2] Univ Edinburgh, Ctr Inflammat Res, Queens Med Res Inst, Edinburgh EH16 4TJ, Midlothian, Scotland

[3] Deutsch Rheuma ForschungZentrum, Immune Regulat Grp, D-10117 Berlin, Germany

来源：

NATURE REVIEWS IMMUNOLOGY | 2008年 / 8卷 / 05期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

D O I：

10.1038/nri2315

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

When B cells react aggressively against self, the potential for pathology is extreme. It is therefore not surprising that B-cell depletion is seen as an attractive therapy in autoimmune diseases. However, B cells can also be essential for restraining unwanted autoaggressive T-cell responses. Recent advances have pointed to interleukin-10 (IL-10) production as a key component in B-cell-mediated immune regulation. In this Opinion article, we develop a hypothesis that triggering of Toll-like receptors controls the propensity of B cells for IL-10 production and immune suppression. According to this model, B cells can translate exposure to certain microbial infections into protection from chronic inflammatory diseases.

引用

页码：391 / 397

页数：7

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