Inflammasomes as molecular mediators of inflammation and cancer: Potential role in melanoma

被引：96

作者：

Dunn, Jeffrey H. ^{[1
]}

Ellis, Lixia Z. ^{[1
]}

Fujita, Mayumi ^{[1
,2
]}

机构：

[1] Univ Colorado Denver, Dept Dermatol, Sch Med, Aurora, CO 80045 USA

[2] Denver Vet Affairs Med Ctr, Denver, CO 80220 USA

来源：

CANCER LETTERS | 2012年 / 314卷 / 01期

关键词：

Inflammasome; Inflammation; Cancer; Melanoma; IL-1; beta; ASC; INTERLEUKIN-1 INDUCES INTERLEUKIN-1; CASPASE RECRUITMENT DOMAIN; INNATE IMMUNE-RESPONSE; FAMILIAL MEDITERRANEAN FEVER; TUMOR-HOST INTERACTIONS; TOLL-LIKE RECEPTORS; SPECK-LIKE PROTEIN; NF-KAPPA-B; NALP3; INFLAMMASOME; IN-VITRO;

D O I：

10.1016/j.canlet.2011.10.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The inflammasome is a multi-protein complex that mediates immune responses to microbial, host, and environmental signals. When active, inflammasomes regulate caspase-1 activation and IL-1 beta secretion. There is a strong link between inflammation and cancer, and IL-1 beta is one of the major molecules involved in both of these disease processes. Here we review the role of inflammasomes in regulating IL-1 beta secretion, and the impact of this pathway on cancer pathogenesis, with a focus on melanoma. This represents an exciting new area of research, and could potentially result in new targets for melanoma therapeutics in the future. Published by Elsevier Ireland Ltd.

引用

页码：24 / 33

页数：10

共 164 条

[1] Toll-like receptors in the induction of the innate immune response [J].

Aderem, A ;

Ulevitch, RJ .

NATURE, 2000, 406 (6797) :782-787

[2] NALP3 forms an IL-lβ-Processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder [J].

Agostini, L ;

Martinon, F ;

Burns, K ;

McDermott, MF ;

Hawkins, PN ;

Tschopp, J .

IMMUNITY, 2004, 20 (03) :319-325

[3] Toll-like receptors: critical proteins linking innate and acquired immunity [J].

Akira, S ;

Takeda, K ;

Kaisho, T .

NATURE IMMUNOLOGY, 2001, 2 (08) :675-680

[4] De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID) -: A new member of the expanding family of pyrin-associated autoinflammatory diseases [J].

Aksentijevich, I ;

Nowak, M ;

Mallah, M ;

Chae, JJ ;

Watford, WT ;

Hofmann, SR ;

Stein, L ;

Russo, R ;

Goldsmith, D ;

Dent, P ;

Rosenberg, HF ;

Austin, F ;

Remmers, EF ;

Balow, JE ;

Rosenzweig, S ;

Komarow, H ;

Shoham, NG ;

Wood, G ;

Jones, J ;

Mangra, N ;

Carrero, H ;

Adams, BS ;

Moore, TL ;

Schikler, K ;

Hoffman, H ;

Lovell, DJ ;

Lipnick, R ;

Barron, K ;

O'Shea, JJ ;

Kastner, DL ;

Goldbach-Mansky, R .

ARTHRITIS AND RHEUMATISM, 2002, 46 (12) :3340-3348

[5] An Autoinflammatory Disease with Deficiency of the Interleukin-1-Receptor Antagonist [J].

Aksentijevich, Ivona ;

Masters, Seth L. ;

Ferguson, Polly J. ;

Dancey, Paul ;

Frenkel, Joost ;

van Royen-Kerkhoff, Annet ;

Laxer, Ron ;

Tedgard, Ulf ;

Cowen, Edward W. ;

Pham, Tuyet-Hang ;

Booty, Matthew ;

Estes, Jacob D. ;

Sandler, Netanya G. ;

Plass, Nicole ;

Stone, Deborah L. ;

Turner, Maria L. ;

Hill, Suvimol ;

Butman, John A. ;

Schneider, Rayfel ;

Babyn, Paul ;

El-Shanti, Hatem I. ;

Pope, Elena ;

Barron, Karyl ;

Bing, Xinyu ;

Laurence, Arian ;

Lee, Chyi-Chia R. ;

Chapelle, Dawn ;

Clarke, Gillian I. ;

Ohson, Kamal ;

Nicholson, Marc ;

Gadina, Massimo ;

Yang, Barbara ;

Korman, Benjamin D. ;

Gregersen, Peter K. ;

van Hagen, P. Martin ;

Hak, A. Elisabeth ;

Huizing, Marjan ;

Rahman, Proton ;

Douek, Daniel C. ;

Remmers, Elaine F. ;

Kastner, Daniel L. ;

Goldbach-Mansky, Raphaela .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (23) :2426-2437

[6] The inflammatory micro-environment in tumor progression: The role of tumor-associated macrophages [J].

Allavena, Paola ;

Sica, Antonio ;

Solinas, Graziella ;

Porta, Chiara ;

Mantovani, Alberto .

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2008, 66 (01) :1-9

[7] The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer [J].

Allen, Irving C. ;

TeKippe, Erin McElvania ;

Woodford, Rita-Marie T. ;

Uronis, Joshua M. ;

Holl, Eda K. ;

Rogers, Arlin B. ;

Herfarth, Hans H. ;

Jobin, Christian ;

Ting, Jenny P. -Y. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2010, 207 (05) :1045-1056

[8] Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf [J].

Amer, Amal ;

Franchi, Luigi ;

Kanneganti, Thirumala-Devi ;

Body-Malapel, Mathilde ;

Ozoren, Nesrin ;

Brady, Graham ;

Meshinchi, Sasha ;

Jagirdar, Rajesh ;

Gewirtz, Andrew ;

Akira, Shizuo ;

Nunez, Gabriel .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (46) :35217-35223

[9] Phospholipases C and A2 control lysosome-mediated IL-1β secretion:: Implications for inflammatory processes [J].

Andrei, C ;

Margiocco, P ;

Poggi, A ;

Lotti, LV ;

Torrisi, MR ;

Rubartelli, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (26) :9745-9750

[10] Effects of micro-environment- and malignant cell-derived interleukin-1 in carcinogenesis, tumour invasiveness and tumour-host interactions [J].

Apte, RN ;

Krelin, Y ;

Song, XP ;

Dotan, S ;

Recih, E ;

Elkabets, M ;

Carmi, Y ;

Dvorkin, T ;

White, RM ;

Gayvoronsky, L ;

Segal, S ;

Voronou, E .

EUROPEAN JOURNAL OF CANCER, 2006, 42 (06) :751-759

← 1 2 3 4 5 6 7 8 9 10 →