Breaking the mitochondrial barrier

被引：802

作者：

Martinou, JC

Green, DR

机构：

[1] Dept Biol Cellulaire, CH-1211 Geneva 4, Switzerland

[2] Serono Pharmaceut Res Inst, Geneva, Switzerland

[3] La Jolla Inst Allergy & Immunol, San Diego, CA 92121 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2001年 / 2卷 / 01期

关键词：

D O I：

10.1038/35048069

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Pro- and anti-apoptotic members of the Bcl-2 family control the permeability of the outer mitochondrial membrane. They could do this either by forming autonomous pores in the membrane or by collaborating with components of the permeability transition pore. Here we discuss why we favour the first of these possibilities.

引用

页码：63 / 67

页数：5

共 46 条

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