The liquid-ordered state comes of age

被引：82

作者：

Mouritsen, Ole G. ^{[1
]}

机构：

[1] Univ So Denmark, MEMPHYS Ctr Biomembrane Phys, Dept Chem & Phys, DK-5230 Odense M, Denmark

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 2010年 / 1798卷 / 07期

基金：

新加坡国家研究基金会;

关键词：

Lipid bilayer; Liquid-ordered phase; Cholesterol; Lipid domains; PHASE-EQUILIBRIA; LIPID RAFTS; CHOLESTEROL; MEMBRANES; ORGANIZATION; MODULATION; MIXTURES; VESICLES; MODEL; NMR;

D O I：

10.1016/j.bbamem.2010.02.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Biomembranes are unique states of soft matter that share some of their materials properties with the mesophases of liquid crystals. Although of genuinely fluid character, membranes can display ordered states under physiological conditions, and it appears that their lateral organization and the related functional properties are intimately coupled to states in-between order and disorder. Hence, the liquid-ordered state of membranes, which owes its existence to the unique ability of cholesterol to mediate between order and disorder, has moved center stage in the characterization of membranes in terms of domains or rafts. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：1286 / 1288

页数：3

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