Vitamin A and the regulation of fat reserves

被引:153
作者
Bonet, ML [1 ]
Ribot, J [1 ]
Felipe, F [1 ]
Palou, A [1 ]
机构
[1] Univ Illes Balears, Dept Biol Fonamental & Ciencias Salut, Lab Biol Mol Nutr & Biotecnol, E-07071 Palma de Mallorca, Spain
关键词
retinoic acid; uncoupling proteins; thermogenesis; UCP1; UCP2; UCP3; adipogenesis; PPAR gamma;
D O I
10.1007/s00018-003-2290-x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Beyond their classical nutritional roles, nutrients modify gene expression and function in target cells and, by so doing, affect many fundamental biological processes. An emerging example, which is the focus of this review, is the involvement of vitamin A in the regulation of the level and functioning of body fat reserves. Retinoic acid, the carboxylic acid form of vitamin A, is a transcriptional activator of the genes encoding uncoupling proteins, and results in animals indicate that whole body thermogenic capacity is related to the vitamin A status. Retinoic acid also influences adipocyte differentiation and survival, with high doses inhibiting and low doses promoting adipogenesis of preadipose cells in culture. Moreover, vitamin A status can influence the development and function of adipose tissues in whole animals, with a low vitamin A status favouring increased fat deposition.
引用
收藏
页码:1311 / 1321
页数:11
相关论文
共 84 条
[1]   Cloning and characterization of the 5′ flanking region of the human uncoupling protein 3 (UCP3) gene [J].
Acín, A ;
Rodriguez, M ;
Rique, H ;
Canet, E ;
Boutin, JA ;
Galizzi, JP .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 258 (02) :278-283
[2]   Adipose tissue as an endocrine organ [J].
Ailhaud, G .
INTERNATIONAL JOURNAL OF OBESITY, 2000, 24 (Suppl 2) :S1-S3
[3]   The promise of retinoids to fight against cancer [J].
Altucci, L ;
Gronemeyer, H .
NATURE REVIEWS CANCER, 2001, 1 (03) :181-193
[4]   A NOVEL REGULATORY PATHWAY OF BROWN FAT THERMOGENESIS - RETINOIC ACID IS A TRANSCRIPTIONAL ACTIVATOR OF THE MITOCHONDRIAL UNCOUPLING PROTEIN GENE [J].
ALVAREZ, R ;
DEANDRES, J ;
YUBERO, P ;
VINAS, O ;
MAMPEL, T ;
IGLESIAS, P ;
GIRALT, M ;
VILLARROYA, F .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (10) :5666-5673
[5]   Both retinoic-acid-receptor- and retinoid-X-receptor-dependent signalling pathways mediate the induction of the brown-adipose-tissue-uncoupling-protein-1 gene by retinoids [J].
Alvarez, R ;
Checa, M ;
Brun, S ;
Viñas, O ;
Mampel, T ;
Iglesias, R ;
Giralt, M ;
Villarroya, F .
BIOCHEMICAL JOURNAL, 2000, 345 :91-97
[6]   Nuclear hormone receptors and gene expression [J].
Aranda, A ;
Pascual, A .
PHYSIOLOGICAL REVIEWS, 2001, 81 (03) :1269-1304
[7]   Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production [J].
Arsenijevic, D ;
Onuma, H ;
Pecqueur, C ;
Raimbault, S ;
Manning, BS ;
Miroux, B ;
Couplan, E ;
Alves-Guerra, MC ;
Goubern, M ;
Surwit, R ;
Bouillaud, F ;
Richard, D ;
Collins, S ;
Ricquier, D .
NATURE GENETICS, 2000, 26 (04) :435-439
[8]  
Blaner William S., 1994, P229
[9]  
BLANER WS, 1994, J BIOL CHEM, V269, P16559
[10]   INVIVO UPTAKE OF CHYLOMICRON (H-3)-LABELED RETINYL ESTER BY RAT-LIVER - EVIDENCE FOR RETINOL TRANSFER FROM PARENCHYMAL TO NON-PARENCHYMAL CELLS [J].
BLOMHOFF, R ;
HELGERUD, P ;
RASMUSSEN, M ;
BERG, T ;
NORUM, KR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (23) :7326-7330