Correlation between behavioral deficits and decreased brain-derived neurotrofic factor in neonatal meningitis

被引：32

作者：

Barichello, Tatiana ^{[1
,2
]}

Belarmino, Eraldo, Jr. ^{[1
,2
]}

Comim, Clarissa M. ^{[2
,4
]}

Cipriano, Andreza L. ^{[1
,2
]}

Generoso, Jaqueline S. ^{[1
,2
]}

Savi, Geovana D. ^{[1
,2
]}

Stertz, Laura ^{[5
,6
]}

Kapczinski, Flavio ^{[5
,6
]}

Quevedo, Joao ^{[2
,3
,4
]}

机构：

[1] Univ Extremo Catarinense, Lab Expt Microbiol, PPGCS, UNASAU, BR-88806000 Criciuma, SC, Brazil

[2] Univ Extremo Catarinense, Inst Nacl Ciencia & Tecnol Translat Med, PPGCS, UNASAU, BR-88806000 Criciuma, SC, Brazil

[3] Hosp Sao Jose, Ctr Pesquisa, Lab Psiquiatria Translat, BR-88801250 Criciuma, SC, Brazil

[4] Univ Extremo Catarinense, Lab Neurociencias, PPGCS, UNASAU, BR-88806000 Criciuma, SC, Brazil

[5] Hosp Clin Porto Alegre, Ctr Pesquisas, Lab Mol Psychiat, BR-90035003 Porto Alegre, RS, Brazil

[6] Hosp Clin Porto Alegre, Ctr Pesquisas, Natl Inst Translat Sci & Technol Med, BR-90035003 Porto Alegre, RS, Brazil

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2010年 / 223卷 / 1-2期

关键词：

Bacterial meningitis; Streptococcus pneumoniae; Neonatal meningitis; Memory; Brain-derived neurotrophic factor; EXPERIMENTAL PNEUMOCOCCAL MENINGITIS; SEPSIS SURVIVOR RATS; BACTERIAL-MENINGITIS; SPATIAL MEMORY; DENTATE GYRUS; INFANT RATS; EXPRESSION; MORBIDITY; MORTALITY; APOPTOSIS;

D O I：

10.1016/j.jneuroim.2010.04.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We investigated the correlation between memory impairment and hippocampal brain-derived neurotrophic factor (BDNF) levels in adult rats submitted to experimental meningitis (Streptococcus pneumoniae) in the neonatal period. Sixty days after inoculation the animals were submitted to the behavior tasks and hippocampal BDNF protein were evaluated. In the meningitis group, there was impairment in habituation and avoidance memory and a decrease in the BDNF levels. The decrease in hippocampal BDNF levels correlated to impairment in memory in adult animals submitted to experimental meningitis in the neonatal period. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：73 / 76

页数：4

共 27 条

[1] Gene and protein expression of galectin-3 and galectin-9 in experimental pneumococcal meningitis [J].