Synthesis, conformational and pharmacological studies on dermorphin N-terminal tetrapeptide analogues

被引：1

作者：

Calderan, A

Ruzza, P

Ancona, B

Cima, L

Giusti, P

Borin, G

机构：

[1] Univ Padua, Dept Organ Chem, CNR, Biopolymer Res Ctr, I-35131 Padua, Italy

[2] Univ Padua, Dept Pharmacol, I-35131 Padua, Italy

来源：

LETTERS IN PEPTIDE SCIENCE | 1998年 / 5卷 / 2-3期

关键词：

dermorphin analogues; opioid peptides; receptor selectivity;

D O I：

10.1007/BF02443441

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dermorphin structure-activity relationships toward mu and delta opioid receptors were investigated using a series of synthetic peptides, in which the aromatic residues at positions 1 or/and 3 of the N-terminal tetrapeptide analogue H-Tyr-D-Arg-Phe-beta-Ala-NH2 were replaced by unnatural or constrained amino acids.

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页码：71 / 73

页数：3

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