Evaluation of urinary PrPSc as a diagnostic test for sporadic, variant, and familial CJD

被引：21

作者：

Head, MW ^{[1
]}

Kouverianou, E ^{[1
]}

Taylor, L ^{[1
]}

Green, A ^{[1
]}

Knight, R ^{[1
]}

机构：

[1] Univ Edinburgh, Sch Mol & Clin Med, CJD Surveillance Unit, Edinburgh EH8 9YL, Midlothian, Scotland

来源：

NEUROLOGY | 2005年 / 64卷 / 10期

关键词：

D O I：

10.1212/01.WNL.0000161842.68793.8A

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Previously collected urine specimens from 100 patients referred to the UK National CJD Surveillance Unit as suspected cases of Creutzfeldt Jakob disease (CJD) were analyzed, testing for abnormal prion protein (PrPSc). In this context, the test had a low sensitivity and was not completely specific for CJD. Additionally, the proteins detected by this assay were not PrPSc but appeared to be immunoglobulins.

引用

页码：1794 / 1796

页数：3

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