An expeditious hydroxyamidation of carboxylic acids

被引：33

作者：

Ech-Chahad, A ^{[1
]}

Minassi, A ^{[1
]}

Berton, L ^{[1
]}

Appendino, G ^{[1
]}

机构：

[1] Univ Piemonte Orientale, Dipartimento Sci Chim Alimentari Farmaceut & Farm, I-28100 Novara, Italy

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 31期

关键词：

hydroxamic acids; hydroxyamidation; fatty acids; PPAA; oleic acid;

D O I：

10.1016/j.tetlet.2005.05.131

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Capitalizing on in situ activation with the cyclic phosphonic anhydride PPAA (1), the conversion of carboxylic acids into hydroxamic acids has been reduced to an experimentally simple one-pot operation that addresses the issue of polyacylation Without resorting to a large excess of hydroxylamine or to protection. Scope and selectivity were satisfactory with a wide range of substrates, including of alpha,beta-tinsaturated acids and hydroxyacids. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：5113 / 5115

页数：3

共 14 条

[1] N-acylvanillamides:: Development of an expeditious synthesis and discovery of new acyl templates for powerful activation of the vanilloid receptor [J].