Arginine vasopressin and angiotensin II receptor binding inhibition by Atractylodes species

被引：5

作者：

Takeda, O

Tsuchiya, K

Kimura, K

Kubo, M

Okada, M

He, SA

机构：

[1] Tsumura & Co, Tsumura Cent Res Labs, Ami, Ibaraki 3001192, Japan

[2] Jiangsu Inst Bot, Nanjing, Peoples R China

来源：

PHARMACEUTICAL BIOLOGY | 2001年 / 39卷 / 03期

关键词：

Atractylodes lancea; angiotensin II; arginine vasopressin; beta-eudesmol; hinesol; receptor binding inhibition; sequiterpenols;

D O I：

10.1076/phbi.39.3.191.5924

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Four known sesquiterpenols (beta -eudesmol, hinesol, elemol, alpha -bisabolol) were isolated from the MeOH extract of the dried rhizomes of Atractylodes lancea. These compounds, moderately (IC50,10(-4)-10(-5)M) inhibited the in vitro binding of [H-3]arginine vasopressin and [H-3] angiotensin II to kidney membrane receptors. The MeOH extracts of Atractylodes plants rhizomes varied in antagonistic activity, which correlated with the variation of beta -eudesmol and hinesol.

引用

收藏

页码：191 / 197

页数：7

相关论文

共 17 条

[1]

NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONISTS - THE DISCOVERY OF A SERIES OF N-(BIPHENYLYLMETHYL)IMIDAZOLES AS POTENT, ORALLY ACTIVE ANTIHYPERTENSIVES [J].

CARINI, DJ ;

DUNCIA, JV ;

ALDRICH, PE ;

CHIU, AT ;

JOHNSON, AL ;

PIERCE, ME ;

PRICE, WA ;

SANTELLA, JB ;

WELLS, GJ ;

WEXLER, RR ;

WONG, PC ;

YOO, SE ;

TIMMERMANS, PBMWM .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (08) :2525-2547

[2]

A FURTHER CONTRIBUTION TO THE SESQUITERPENOID CONSTITUENTS OF CYMBOPOGON-PROXIMUS [J].

ELGAMAL, MH ;

WOLFF, P .

PLANTA MEDICA, 1987, (03) :293-294

[3]

IMAI K, 1991, 111 ANN M PHARM SOC, V4, P249

[4]

LIVER PROTECTIVE DRUGS .9. ANTIHEPATOTOXIC PRINCIPLES OF ATRACTYLODES RHIZOMES [J].

KISO, Y ;

TOHKIN, M ;

HIKINO, H .

JOURNAL OF NATURAL PRODUCTS, 1983, 46 (05) :651-654

[5]

KOBAYASHI M, 1989, Shoyakugaku Zasshi, V43, P230

[6]

TRITERPENOIDS FROM EUPHORBIA-MACULATA [J].

MATSUNAGA, S ;

TANAKA, R ;

AKAGI, M .

PHYTOCHEMISTRY, 1988, 27 (02) :535-537

[7]

STUDIES ON COMPONENTS OF ATRACTYLODES .2. NEW POLYACETYLENIC COMPOUNDS IN RHIZOME OF ATRACTYLODES-LANCEA DE CANDOLLE VAR CHINENSIS KITAMURA [J].

NISHIKAWA, Y ;

YASUDA, I ;

WATANABE, Y ;

SETO, T .

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 1976, 96 (11) :1322-1326

[8]

NISHIKAWA Y, 1975, Shoyakugaku Zasshi, V29, P139

[9]

PHARMACOLOGICAL PROFILE OF GR117289 INVITRO - A NOVEL, POTENT AND SPECIFIC NONPEPTIDE ANGIOTENSIN AT1 RECEPTOR ANTAGONIST [J].

ROBERTSON, MJ ;

BARNES, JC ;

DREW, GM ;

CLARK, KL ;

MARSHALL, FH ;

MICHEL, A ;

MIDDLEMISS, D ;

ROSS, BC ;

SCOPES, D ;

DOWLE, MD .

BRITISH JOURNAL OF PHARMACOLOGY, 1992, 107 (04) :1173-1180

[10]

VASOPRESSIN ANALOGS THAT ANTAGONIZE ANTI-DIURETIC RESPONSES BY RATS TO THE ANTI-DIURETIC HORMONE [J].

SAWYER, WH ;

PANG, PKT ;

SETO, J ;

MCENROE, M ;

LAMMEK, B ;

MANNING, M .

SCIENCE, 1981, 212 (4490) :49-51