The intramolecular addition of an aryl radical to a pyridine provides a short entry to toddaquinoline

被引：39

作者：

Harrowven, DC ^{[1
]}

Nunn, MIT ^{[1
]}

机构：

[1] Univ Southampton, Dept Chem, Southampton SO17 1BJ, Hants, England

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 32期

关键词：

cyclisation; natural products; polycyclic heterocyclic compounds; pyridines; quinolines; radicals and radical reactions; Wittig reactions;

D O I：

10.1016/S0040-4039(98)01187-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The paper describes a synthetic approach to toddaquinoline, an unusual alkaloid from the root bark of Formosan Toddalia asiatica. Key steps are a cis-selective Wittig coupling and a trialkyltin mediated, intramolecular cyclisation of an aryl radical to C-6 of a pyridine. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：5875 / 5876

页数：2

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