Infection of macrophage-like cells by Legionella species that have not been associated with disease

被引：35

作者：

OConnell, WA ^{[1
]}

Dhand, L ^{[1
]}

Cianciotto, NP ^{[1
]}

机构：

[1] NORTHWESTERN UNIV, DEPT MICROBIOL IMMUNOL, CHICAGO, IL 60611 USA

来源：

INFECTION AND IMMUNITY | 1996年 / 64卷 / 10期

关键词：

D O I：

10.1128/IAI.64.10.4381-4384.1996

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We assessed the ability of Legionella species that have not been associated with disease to infect macrophagelike U937 cells. Two of fourteen species tested exhibited a 50% infective dose that was within 1 log unit of that of virulent L. pneumophila. Indeed, intracellular CFU of L. jamestowniensis and L. parisiensis increased 100-fold over a 72-h period. These data indicate that additional legionellae can flourish within phagocytes and therefore, can, if given the opportunity, cause disease.

引用

页码：4381 / 4384

页数：4

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