Concepts and mechanisms of migraine chronification

被引：129

作者：

Bigal, Marcelo E. ^{[1
,2
]}

Lipton, Richard B. ^{[3
]}

机构：

[1] Albert Einstein Coll Med, Dept Neurol, Bronx, NY 10467 USA

[2] Montefiore Headache Ctr, Albert Einstein Coll Med, Dept Neurol, Bronx, NY USA

[3] Montefiore Headache Ctr, Albert Einstein Coll Med, Dept Neurol & Epidemiol & Populat Hlth, Bronx, NY USA

来源：

HEADACHE | 2008年 / 48卷 / 01期

关键词：

chronic migraine; migraine progression; transformation;

D O I：

10.1111/j.1526-4610.2007.00969.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Migraine is a chronic recurrent disorder with episodic manifestations that is progressive in some individuals. Migraine progresses clinically, physiologically, and anatomically. Progression may be a consequence of the mechanisms that generate the migraine attacks (eg, cortical spreading depression) or it may be a function of the activations generated by the attacks (eg, lesions in the periaqueductal gray area), a hypothesis supported by the increase in lesions with attack frequency. Progression may also be partially explained by common genetic or environmental risk factors. Finally, migraine with aura is associated with an elevated Framingham score and with risk factors for cardiovascular disease. Research on this issue is in its infancy and cautions are necessary before extrapolating this information into clinical practice.

引用

页码：7 / 15

页数：9

共 46 条

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