Self-assembly of nucleoamphiphiles:: Investigating nucleosides effect and the mechanism of micrometric helix formation

被引：31

作者：

Aime, Carole

Manet, Sabine

Satoh, Takao

Ihara, Hirotaka

Park, Keon-Young

Godde, Frederic

Oda, Reiko

机构：

[1] Univ Bordeaux 1, CNRS, Inst Europeen Chim Biol, UMR 5248,CBMN,ENITAB,IECB, F-33607 Pessac, France

[2] Kumamoto Univ, Dept Appl Chem & Biochem, Kumamoto 8608555, Japan

来源：

LANGMUIR | 2007年 / 23卷 / 26期

关键词：

D O I：

10.1021/la702105s

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new family of self-assembling systems based on nucleoamphiphiles is described. Nano to micrometric left-handed helix formation in aqueous solution was induced simply by complexing a GMP or an AMP with a nonchiral monocationic amphiphile. The assembling behavior such as micellar formation, monolayer at air-water interface, as well as the aggregates in solution of these nucleoamphiphiles are strongly influenced by the presence 4 nucleosides in solution. The observed effects depend on the properties of complexed nucleotides and nucleosides with a complex mixture of pi stacking, hydrophobicity of the bases, and hydrogen bonding.

引用

收藏

页码：12875 / 12885

页数：11

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