A long-range restriction map across 3 Mb of the chromosome 11 breakpoint region of a translocation linked to schizophrenia: localization of the breakpoint and the search for neighbouring genes

被引：12

作者：

Millar, JK

Brown, J

Maule, JC

Shibasaki, Y

Christie, S

Lawson, D

Anderson, S

Wilson-Annan, JC

Devon, RS

St Clair, DM

Blackwood, DHR

Muir, WJ

Porteous, DJ

机构：

[1] Western Gen Hosp, MRC, Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland

[2] Univ Aberdeen, Dept Mental Hlth, Aberdeen AB9 1FX, Scotland

[3] Western Gen Hosp, Mol Med Ctr, Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland

[4] Univ Edinburgh, Royal Edinburgh Hosp, Dept Psychiat, Edinburgh EH10 5HF, Midlothian, Scotland

来源：

PSYCHIATRIC GENETICS | 1998年 / 8卷 / 03期

关键词：

schizophrenia; translocation; long-range restriction map; gene identification;

D O I：

10.1097/00041444-199800830-00007

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A balanced t(1;11)(q42.1;q14.3) translocation segregates with schizophrenia and related mental illness in a single large Scottish pedigree. We have constructed a long-range restriction map covering at least 3 Mb of the chromosome 11 breakpoint region and conducted searches for genes whose expression could be altered by the translocation, resulting in schizophrenia. Novel transcribed sequences of unknown function clustered around putative CpG islands, located approximately 500 kb and 700 kb above the breakpoint, represent the only evidence to date for expressed genes within the mapped region. Psychiatr Genet 8:175-181 (C) 1998 Lippincott Williams & Wilkins.

引用

页码：175 / 181

页数：7

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