Chemokines and their receptors: Drug targets in immunity and inflammation

被引：444

作者：

Viola, Antonella ^{[1
,2
,3
]}

Luster, Andrew D.

机构：

[1] Univ Milan, Ist Patol Gen, I-20133 Milan, Italy

[2] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Ctr Immunol & Inflammatory Dis,Div Rheumatol Alle, Boston, MA 02114 USA

[3] IRCCS, Ist Clin Humanitas, I-20089 Milan, Italy

来源：

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY | 2008年 / 48卷

关键词：

leukocytes; chemotaxis; disease; drug discovery;

D O I：

10.1146/annurev.pharmtox.48.121806.154841

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The chemokine system coordinates leukocyte migration in immunity and inflammation and is implicated in the pathogenesis of many human diseases. Although several successful strategies have been identified to develop drugs targeting chemokines and their receptors, this has not yet resulted in many new therapeutics. This is likely due to a complexity of the chemokine system, which was not initially appreciated, that is characterized by redundancy, pleiotropy, and differences among species. Nevertheless, our understanding of chemokine biology is continuing to grow and several promising drugs are currently being tested in late-stage clinical trials. In this review, we examine the role of chemokines in health and diseases and discuss strategies to target the chemokine system.

引用

页码：171 / 197

页数：27

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