Cross-couplings of unactivated secondary alkyl halides: Room-temperature nickel-catalyzed Negishi reactions of alkyl bromides and iodides

被引：287

作者：

Zhou, JR ^{[1
]}

Fu, GC ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 48期

关键词：

D O I：

10.1021/ja0389366

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The development of a nickel- or palladium-catalyzed method for cross-coupling unactivated secondary alkyl halides has been a long-standing challenge in synthetic chemistry. This communication describes a simple catalyst system-Ni(cod)2/s-Bu-Pybox-that achieves room-temperature Negishi reactions of an array of functionalized primary and secondary alkyl bromides and iodides. Copyright © 2003 American Chemical Society.

引用

页码：14726 / 14727

页数：2

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