LKB1 and AMPK in cell polarity and division

被引：121

作者：

Williams, Tyisha

Brenman, Jay E. ^{[1
]}

机构：

[1] Univ N Carolina, Sch Med, Dept Cell & Dev Biol, Chapel Hill, NC 27599 USA

来源：

TRENDS IN CELL BIOLOGY | 2008年 / 18卷 / 04期

关键词：

D O I：

10.1016/j.tcb.2008.01.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

LKB1 and AMP-activated protein kinase (AMPK) are serine-threonine kinases implicated in key cellular pathways, including polarity establishment and energy sensing, respectively. Recent in vivo analyses in Drosophila have demonstrated vital roles for both AMPK and LKB1 in part through the myosin regulatory light chain - in cell polarity and cell division. Evidence from mammalian experiments also supports non-metabolic functions for LKB1 and AMPK. This review examines unanticipated AMPK functions for initiating and maintaining cell polarity and completing normal cell division. The ability of AMPK to sense energy status might be coupled with fundamental cell biological functions.

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收藏

页码：193 / 198

页数：6

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