Vitamin D Effects on Bone and Muscle

被引:22
作者
Bischoff-Ferrari, Heike [2 ,4 ,5 ]
Staehelin, Hannes B. [1 ]
Walter, Paul [3 ]
机构
[1] Univ Basel Hosp, Geriatr Univ Clin, Memory Clin, CH-4031 Basel, Switzerland
[2] Univ Zurich, Ctr Aging & Mobil, Zurich, Switzerland
[3] Univ Basel, Basel, Switzerland
[4] Univ Zurich Hosp, Dept Rheumatol, CH-8091 Zurich, Switzerland
[5] Univ Zurich Hosp, Inst Med Phys, CH-8091 Zurich, Switzerland
关键词
Vitamin D; fractures; falls; prevention; chronic diseases; bone density; threshold; optimal benfit; HIP FRACTURE; CALCIUM SUPPLEMENTATION; DIETARY CALCIUM; ELDERLY-PEOPLE; DOUBLE-BLIND; D DEFICIENCY; FALLS; RISK; PREVENTION; CHOLECALCIFEROL;
D O I
10.1024/0300-9831/a000072
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Increasing data suggest that higher 25-hydroxyvitamin D [25(OH)D] serum concentrations are advantageous for health. At present, strong evidence for causality is available for fracture and fall prevention, while promising epidemiologic and mechanistic studies suggest a key role of vitamin Din the preservation of cardiovascular health, and the prevention of cancer and other common chronic disease. For lower extremity function, fall prevention, hip bone density, and for fracture prevention optimal benefits are observed with 25(OH)D levels of at least 75 nmol/L to 100 nmol/L [1]. This threshold may be reached in 50% of adults with 800 to 1000 IU vitamin D per day. This manuscript will discuss the evidence of vitamin D in fall and fracture prevention and how these data transfer to the most recent recommendations by the IOF (International Osteoporosis Foundation) and the IOM (Institute of Medicine).
引用
收藏
页码:264 / 272
页数:9
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