Niacin mediates lipolysis in adipose tissue through its G-protein coupled receptor HM74A

被引：66

作者：

Zhang, YY ^{[1
]}

Schmidt, RJ ^{[1
]}

Foxworthy, P ^{[1
]}

Emkey, R ^{[1
]}

Oler, JK ^{[1
]}

Large, TH ^{[1
]}

Wang, H ^{[1
]}

Su, EW ^{[1
]}

Mosior, MK ^{[1
]}

Eacho, PI ^{[1
]}

Cao, GQ ^{[1
]}

机构：

[1] Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2005年 / 334卷 / 02期

关键词：

niacin; nicotinic acid; lipolysis; adipocyte; cAMP; GPCR;

D O I：

10.1016/j.bbrc.2005.06.141

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A G-protein coupled receptor to niacin (nicotinic acid) was identified recently but the physiological/pharmacological role of the receptor remains poorly defined. We present our studies to demonstrate that HM74A, but not HM74, binds niacin at high affinities and effectively mediates Gi signaling events in human embryonic kidney HEK293 cells as well as in 3T3L1 adipocytes expressing HM74A. Furthermore, HM74A, but not HM74, expressed in differentiated 3T3L1 adipocytes effectively mediated inhibition of lipolysis by niacin. Our results provided direct evidence indicating that HM74A, but not HN174, was sufficient to mediate anti-lipolytic effect of niacin in adipose tissue. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：729 / 732

页数：4

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