Coxsackie virus infection of the placenta associated with neurodevelopmental delays in the newborn

被引:84
作者
Euscher, E
Davis, J
Holzman, I
Nuovo, GJ
机构
[1] Ohio State Univ, Med Ctr, Dept Pathol, Columbus, OH 43210 USA
[2] SUNY Stony Brook, Winthrop Univ Hosp, Sch Med, Dept Pediat Neonatol, Mineola, NY 11501 USA
[3] CUNY Mt Sinai Sch Med, New York, NY 10029 USA
关键词
D O I
10.1016/S0029-7844(01)01625-8
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To determine if viral infection of the placenta was associated with long-term neurodevelopmental delays in the newborn. Methods: Placental tissue from seven newborn infants with severe respiratory failure and subsequent neurodevelopmental abnormalities as well as ten normal controls and five cases of known placental infection (cytomegalovirus, herpes simplex virus, and parvovirus) were tested by in situ hybridization or reverse transcriptase in situ polymerase chain reaction (PCR) for adenovirus, coxsackie virus, cytomegalovirus, Epstein Barr virus, herpes simplex virus, influenza A virus, picornavirus, polyoma virus, parvovirus, respiratory syncytial virus, rotavirus, and varicella zoster virus. Results: Coxsackie virus PNA was detected in six of the seven cases, and in none of the ten normal controls or five cases with known viral infection. Viral RNA localized primarily to the Hofbauer cells and trophoblasts of the terminal villi. Immunohistochemical analysis for the coxsackie virus antigen VP1 yielded equivalent results. Conclusions: In utero coxsackie virus of the placenta is associated with the development of severe respiratory failure and central nervous system sequelae in the newborn. This underscores the importance of detailed pathologic and viral examination of the placenta in cases of systemic illness in the newborn. (Obstet Gynecol 2001;98: 1019-26. (C) 2001 by the American College of Obstetricians and Gynecologists.).
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页码:1019 / 1026
页数:8
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