Cytokines and chemokines in the epidermis

被引：122

作者：

Uchi, H ^{[1
]}

Terao, H ^{[1
]}

Koga, T ^{[1
]}

Furue, M ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Med Sci, Dept Dermatol, Fukuoka 8128582, Japan

来源：

JOURNAL OF DERMATOLOGICAL SCIENCE | 2000年 / 24卷

关键词：

keratinocyte; Langerhans cell; dendritic cell; cytokine; chemokine;

D O I：

10.1016/S0923-1811(00)00138-9

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Keratinocytes (KC) produce a vast repertoire of cytokines, including interleukins, growth factors, colony stimulating factors, and chemokines. Under normal conditions, most of them are not synthesized or remain in the cytoplasm, but external stimuli, such as trauma, bacterial infections, chemical substances, or ultraviolet irradiation induce the production and release of these cytokines from KC. KC-derived cytokines regulate the immune and inflammatory responses through their receptors on KC, Langerhans cells, dermal fibroblasts and endothelial cells, and infiltrating T-cells. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：S29 / S38

页数：10

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