A polymerization-depolymerization model that accurately generates the self-sustained oscillatory system involved in bacterial division site placement

被引：56

作者：

Drew, DA

Osborn, MJ

Rothfield, LI ^{[1
]}

机构：

[1] Univ Connecticut, Ctr Hlth, Dept Mol Microbial & Struct Biol, Farmington, CT 06032 USA

[2] Rensselaer Polytech Inst, Dept Math Sci, Troy, NY 12180 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2005年 / 102卷 / 17期

关键词：

Min; cell division; cytoskeleton;

D O I：

10.1073/pnas.0502037102

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Determination of the proper site ford division in Escherichia coli and other bacteria involves a unique spatial oscillatory system in which membrane-associated structures composed of the MinC, MinD and MinE proteins oscillate rapidly between the two cell poles. In vitro evidence indicates that this involves ordered cycles of assembly and disassembly of MinD polymers. We propose a mathematical model to explain this behavior. Unlike previous attempts, the present approach is based on the expected behavior of polymerization-depolymerization systems and incorporates current knowledge of the biochemical properties of MinD and MinE. Simulations based on the model reproduce all of the known topological and temporal characteristics of the in vivo oscillatory system.

引用

页码：6114 / 6118

页数：5

共 23 条

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