Low levels of antipertussis antibodies plus lack of history of pertussis correlate with susceptibility after household exposure to Bordetella pertussis

被引：92

作者：

Storsaeter, J ^{[1
]}

Hallander, HO ^{[1
]}

Gustafsson, L ^{[1
]}

Olin, P ^{[1
]}

机构：

[1] Swedish Inst Infect Dis Control, Solna, Sweden

来源：

VACCINE | 2003年 / 21卷 / 25-26期

关键词：

antipertussis antibodies; susceptibility; Bordetella pertussis;

D O I：

10.1016/S0264-410X(03)00407-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Prospectively collected data in a Swedish vaccine efficacy trial were used to investigate transmission of pertussis from small study infants to other household members. Forty one percent (258/627) of the exposed persons with paired serology had laboratory confirmed pertussis. The majority of those with laboratory confirmed pertussis had less than 14 days of cough and many were asymptomatic. High susceptibility to symptomatic pertussis was found among persons with low initial IgG antibody concentrations against pertussis toxin, especially those without previous history of pertussis vaccination or disease. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：3542 / 3549

页数：8

共 39 条

[1] CLONING, EXPRESSION, AND DNA-SEQUENCE ANALYSIS OF GENES ENCODING NONTYPABLE HAEMOPHILUS-INFLUENZAE HIGH-MOLECULAR-WEIGHT SURFACE-EXPOSED PROTEINS RELATED TO FILAMENTOUS HEMAGGLUTININ OF BORDETELLA-PERTUSSIS [J].