Deconstructing the LDL receptor - a rhapsody in pieces

被引：13

作者：

Herz, J ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr, Dept Mol Genet, Dallas, TX 75390 USA

来源：

NATURE STRUCTURAL BIOLOGY | 2001年 / 8卷 / 06期

关键词：

D O I：

10.1038/88519

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The LDL receptor plays a central role in the control of plasma cholesterol levels and the prevention of coronary artery disease. Recent studies now shed light on the structural organization of several independently folded modules and domains from which the receptor is assembled, providing substantial insights into the mechanics of receptor function and the consequences of disease causing mutations.

引用

页码：476 / 478

页数：3

共 14 条

[1] Folding, calcium binding, and structural characterization of a concatemer of the first and second ligand-binding modules of the low-density lipoprotein receptor [J].

Bieri, S ;

Atkins, AR ;

Lee, HT ;

Winzor, DJ ;

Smith, R ;

Kroon, PA .

BIOCHEMISTRY, 1998, 37 (31) :10994-11002

[2] Protein folding and calcium binding defects arising from familial hypercholesterolemia mutations of the LDL receptor [J].

Blacklow, SC ;

Kim, PS .

NATURE STRUCTURAL BIOLOGY, 1996, 3 (09) :758-762

[3] 3-DIMENSIONAL STRUCTURE OF A CYSTEINE-RICH REPEAT FROM THE LOW-DENSITY-LIPOPROTEIN RECEPTOR [J].

DALY, NL ;

SCANLON, MJ ;

DJORDJEVIC, JT ;

KROON, PA ;

SMITH, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (14) :6334-6338

[4] ACID-DEPENDENT LIGAND DISSOCIATION AND RECYCLING OF LDL RECEPTOR MEDIATED BY GROWTH-FACTOR HOMOLOGY REGION [J].

DAVIS, CG ;

GOLDSTEIN, JL ;

SUDHOF, TC ;

ANDERSON, RGW ;

RUSSELL, DW ;

BROWN, MS .

NATURE, 1987, 326 (6115) :760-765

[5] Molecular basis of familial hypercholesterolaemia from structure of LDL receptor module [J].

Fass, D ;

Blacklow, S ;

Kim, PS ;

Berger, JM .

NATURE, 1997, 388 (6643) :691-693

[6]

Goldstein J., 2001, The metabolic and molecular bases of inherited disease, P2863

[7] The LDL receptor gene family: (Un)expected signal transducers in the brain [J].

Herz, J .

NEURON, 2001, 29 (03) :571-581

[8]

JEON, 2001, NATURE STRUCT BIOL, V8, P499

[9] NMR structure of a concatemer of the first and second ligand-binding modules of the human low-density lipoprotein receptor [J].

Kurniawan, ND ;

Atkins, AR ;

Bieri, S ;

Brown, CJ ;

Brereton, IM ;

Kroon, PA ;

Smith, R .

PROTEIN SCIENCE, 2000, 9 (07) :1282-1293

[10] The first epidermal growth factor-like domain of the low-density lipoprotein receptor contains a noncanonical calcium binding site [J].

Malby, S ;

Pickering, R ;

Saha, S ;

Smallridge, R ;

Linse, S ;

Downing, AK .

BIOCHEMISTRY, 2001, 40 (08) :2555-2563

← 1 2 →