Cell biology of tubotympanum in relation to pathogenesis of otitis media - a review

被引：86

作者：

Lim, DJ ^{[1
]}

Chun, YM ^{[1
]}

Lee, HY ^{[1
]}

Moon, SK ^{[1
]}

Chang, KH ^{[1
]}

Li, JD ^{[1
]}

Andalibi, A ^{[1
]}

机构：

[1] House Ear Res Inst, Leslie & Susan Gonda Dept Cell & Mol Biol, Los Angeles, CA USA

来源：

VACCINE | 2000年 / 19卷

关键词：

tubotympanum; otitis media pathogenesis; innate immunity;

D O I：

10.1016/S0264-410X(00)00273-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The sterility of the eustachian tube and tympanic cavity of normal individuals is maintained not only by the adaptive immune system, but also by the mucociliary system and the antimicrobial molecules of innate immunity. Mucin production and periciliary fluid homeostasis are essential for normal mucociliary function and dysfunction of this system is an important risk factor for otitis media. The secreted antimicrobial molecules of the tubotympanum include lysozyme, lactoferrin, beta defensins, and the surfactant proteins A and D (SP-A, SP-D). Defects in the expression or regulation of these molecules may also be the major risk factor for otitis media. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：S17 / S25

页数：9

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