Hyperexcitability: Exaggerated fear-potentiated startle produced by partial amygdala kindling

被引：73

作者：

Rosen, JB

Hamerman, E

Sitcoske, M

Glowa, JR

Schulkin, J

机构：

[1] NIMH,BIOL PSYCHIAT BRANCH,BETHESDA,MD

[2] NIMH,CLIN NEUROENDOCRINOL BRANCH,BETHESDA,MD

[3] NIDDK,MED CHEM LAB,BETHESDA,MD 20892

来源：

BEHAVIORAL NEUROSCIENCE | 1996年 / 110卷 / 01期

关键词：

D O I：

10.1037/0735-7044.110.1.43

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The present study asked whether partial amygdala kindling would affect the expression of conditioned fear-potentiated startle. Rats were conditioned to be fearful of a light. They were then stimulated bilaterally in the amygdala or hippocampus on 2 consecutive days (partial kindling). Rats were tested 24 hr later for fear-potentiated startle. Amygdala-kindled rats had exaggerated fear-potentiated startle compared to sham-kindled rats. Hippocampus-kindled rats also displayed fear-potentiated startle, but no greater than that of sham-kindled rats. Partial amygdala kindling induced c-fos messenger RNA (mRNA) expression, a marker for neuronal activation, throughout the limbic and neocortices. In contrast, partial hippocampus kindling induced c-fos mRNA in the hippocampus only. The data suggest that kindled-induced hyperexcitability of the amygdala and limbic cortices produced exaggerated conditioned fear-potentiated startle.

引用

页码：43 / 50

页数：8

共 58 条

[1] INDIVIDUAL-DIFFERENCES IN TEMPORAL-LOBE SENSORY PROCESSING OF THREATENING STIMULI IN THE CAT [J].