EPR evidence for the involvement of free radicals in the iron-catalysed decomposition of qinghaosu (Artemisinin) and some derivatives; Antimalarial action of some polycyclic endoperoxides

被引：83

作者：

Butler, AR

Gilbert, BC ^{[1
]}

Hulme, P

Irvine, LR

Renton, L

Whitwood, AC

机构：

[1] Univ York, Dept Chem, York YO1 5DD, N Yorkshire, England

[2] Univ St Andrews, Sch Chem, St Andrews KY16 9ST, Fife, Scotland

来源：

FREE RADICAL RESEARCH | 1998年 / 28卷 / 05期

关键词：

alkoxyl antimalarial; artemisinin; electron paramagnetic resonance; peroxides; peroxygen; qinghaosu; radical-rearrangement; radical-fragmentation; spin-trapping;

D O I：

10.3109/10715769809066884

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

EPR experiments confirm that reaction of qinghaosu and some related endoperoxides with Fe2+ in aqueous acetonitrile leads to the production of carbon-centred radicals derived by rapid rearrangement of first-formed cyclic alkoxyl radicals. Signals obtained from qinghaosu itself with spin-traps DMPO and DBNBS are assigned to the adducts (15) and (16), a finding which accounts for the formation of the major products (11) and (14).

引用

页码：471 / 476

页数：6

共 20 条

[1] RADICAL SPECIES PRODUCED FROM THE PHOTOLYTIC AND PULSE-RADIOLYTIC DEGRADATION OF TERT-BUTYL HYDROPEROXIDE - AN EPR SPIN TRAPPING INVESTIGATION [J].