Role of the JNK signal transduction pathway in inflammatory bowel disease

被引：170

作者：

Roy, Praveen K. ^{[1
]}

Rashid, Farzana ^{[1
]}

Bragg, Jack ^{[1
]}

Ibdah, Jamal A. ^{[1
]}

机构：

[1] Univ Missouri, Sch Med, Div Gastroenterol & Hepatol, Columbia, MO USA

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2008年 / 14卷 / 02期

关键词：

JNK pathway; inflammatory bowel disease; inflammation;

D O I：

10.3748/wjg.14.200

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The c-Jun NH2-terminal Kinase (JNK) pathway represents one sub-group of the mitogen-activated protein (MAP) kinases which plays an important role in various inflammatory diseases states, including inflammatory bowel disease (IBD). Significant progress towards understanding the function of the INK signaling pathway has been achieved during the past few years. Blockade of the INK pathway with INK inhibitors in animal models of IBD lead to resolution of intestinal inflammation. Current data suggest specific INK inhibitors hold promise as novel therapies in IBD. (c) 2008 WJG. All rights reserved.

引用

页码：200 / 202

页数：3

共 17 条

[1]

Transcription factor and kinase-mediated signaling in atherosclerosis and vascular injury [J].

Adhikari N. ;

Charles N. ;

Lehmann U. ;

Hall J.L. .

Current Atherosclerosis Reports, 2006, 8 (3) :252-260

[2]

The specific JNK inhibitor SP600125 targets tumour necrosis factor-α production and epithelial cell apoptosis in acute murine colitis [J].

Assi, K ;

Pillai, R ;

Gómez-Muñoz, A ;

Owen, D ;

Salh, B .

IMMUNOLOGY, 2006, 118 (01) :112-121

[3]

Critical role of nuclear factor-κB and stress-activated protein kinases in steroid unresponsiveness [J].

Bantel, H ;

Schmitz, ML ;

Raible, A ;

Gregor, M ;

Schulze-Osthoff, K .

FASEB JOURNAL, 2002, 16 (13) :1832-+

[4]

The c-Jun N-terminal protein kinase family of mitogen-activated protein kinases (JNK MAPKs) [J].

Barr, RK ;

Bogoyevitch, MA .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2001, 33 (11) :1047-1063

[5]

Future therapies for inflammatory bowel disease [J].

Stephen J. Bickston ;

Lawrence W. Comerford ;

Fabio Cominelli .

Current Gastroenterology Reports, 2003, 5 (6) :518-523

[6]

The isoform-specific functions of the c-Jun N-terminal kinases (JNKs): differences revealed by gene targeting [J].

Bogoyevitch, Marie A. .

BIOESSAYS, 2006, 28 (09) :923-934

[7]

Genetic deletion of JNK1 and JNK2 aggravates the DSS-induced colitis in mice [J].

Chromik, A. M. ;

Mueller, A. M. ;

Koerner, J. ;

Belyaev, O. ;

Holland-Letz, T. ;

Schmitz, F. ;

Herdegen, T. ;

Uhl, W. ;

Mittelkoetter, U. .

JOURNAL OF INVESTIGATIVE SURGERY, 2007, 20 (01) :23-33

[8]

JNK pathway: diseases and therapeutic potential [J].

Cui, Jie ;

Zhang, Ming ;

Zhang, Yong-qing ;

Xu, Zhi-heng .

ACTA PHARMACOLOGICA SINICA, 2007, 28 (05) :601-608

[9]

Han ZN, 2001, J CLIN INVEST, V108, P73, DOI 10.1172/JCI12466

[10]

The c-jun kinase/stress-activated pathway: Regulation, function and role in human disease [J].

Johnson, Gary L. ;

Nakamura, Kazuhiro .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2007, 1773 (08) :1341-1348

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