Expression of the Sox10 gene during mouse inner ear development

被引：50

作者：

Watanabe, K

Takeda, K

Katori, Y

Ikeda, K

Oshima, T

Yasumoto, K

Saito, H

Takasaka, T

Shibahara, S

机构：

[1] Tohoku Univ, Sch Med, Dept Mol Biol & Appl Physiol, Aoba Ku, Sendai, Miyagi 9808575, Japan

[2] Tohoku Univ, Sch Med, Dept Otorhinolaryngol, Aoba Ku, Sendai, Miyagi 9808574, Japan

来源：

MOLECULAR BRAIN RESEARCH | 2000年 / 84卷 / 1-2期

关键词：

Sox10; inner ear; cochlea; organ of Corti; supporting cell; otic vesicle;

D O I：

10.1016/S0169-328X(00)00236-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Mutations in the SOX10 gene, encoding a cell-lineage specific transcription factor, are associated with congenital deafness. We analyzed the expression of Sox10 mRNA in developing mouse inner ear by in situ hybridization. Sox10 mRNA is expressed in the entire epithelia of the otic vesicle at embryonic day 11.5 (E11.5) and in the developing cochlea and vestibule at E13.5. In postnatal day 8 and adult cochleas, Sox10 expression is restricted to the supporting cells of the organ of Corti. These expression profiles suggest that Sox10 is important for development of the cochlea. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

收藏

页码：141 / 145

页数：5

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