DNA vaccination with the human immunodeficiency virus type 1 SF162ΔV2 envelope elicits immune responses that offer partial protection from simian/human immunodeficiency virus infection to CD8+ T-cell-depleted rhesus macaques

被引：77

作者：

Cherpelis, S

Shrivastava, I

Gettie, A

Jin, X

Ho, DD

Barnett, SW

Stamatatos, L

机构：

[1] Rockefeller Univ, Aaron Diamond AIDS Res Ctr, New York, NY 10016 USA

[2] Chiron Corp, Emeryville, CA 94608 USA

[3] Tulane Reg Primate Res Ctr, Covington, LA 70433 USA

来源：

JOURNAL OF VIROLOGY | 2001年 / 75卷 / 03期

关键词：

D O I：

10.1128/JVI.75.3.1547-1550.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

DNA immunization of macaques with the SF162 Delta V2 envelope elicited lymphoproliferative responses and potent neutralizing antibodies. The animals were depleted of their CD8(+) T lymphocytes and then challenged intravenously with SHIV162P4. Compared to unvaccinated animals, the vaccinated macaques had lower peak viremia levels, rapidly cleared plasma virus, and showed delayed seroconversion.

引用

页码：1547 / 1550

页数：4

共 22 条

[1] An HIV type 2 DNA vaccine induces cross-reactive immune responses against HIV type 2 and SIV
Agadjanyan, MG
Trivedi, NN
Kudchodkar, S
Bennet, M
Levine, W
Lin, A
Boyer, J
Levy, D
Ugen, KE
Kim, JJ
Weiner, DB
[J]. AIDS RESEARCH AND HUMAN RETROVIRUSES, 1997, 13 (18) : 1561 - 1572
[2] Barnett SW, 1998, AIDS RES HUM RETROV, V14, pS299
[3] Protection of chimpanzees from high-dose heterologous HIV-1 challenge by DNA vaccination
Boyer, JD
Ugen, KE
Wang, B
Agadjanyan, M
Gilbert, L
Bagarazzi, ML
Chattergoon, M
Frost, P
Javadian, A
Williams, WV
Refaeli, Y
Ciccarelli, RB
McCallus, D
Coney, L
Weiner, DB
[J]. NATURE MEDICINE, 1997, 3 (05) : 526 - 532
[4] In vivo protective anti-HIV immune responses in non-human primates through DNA immunization
Boyer, JD
Wang, B
Ugen, KE
Agadjanyan, M
Javadian, A
Frost, P
Dang, KS
Carrano, RA
Ciccarelli, R
Coney, L
Williams, WV
Weiner, DB
[J]. JOURNAL OF MEDICAL PRIMATOLOGY, 1996, 25 (03) : 242 - 250
[5] EFFECT OF INTRON-A FROM HUMAN CYTOMEGALOVIRUS (TOWNE) IMMEDIATE-EARLY GENE ON HETEROLOGOUS EXPRESSION IN MAMMALIAN-CELLS
CHAPMAN, BS
THAYER, RM
VINCENT, KA
HAIGWOOD, NL
[J]. NUCLEIC ACIDS RESEARCH, 1991, 19 (14) : 3979 - 3986
[6] Distinct pathogenic sequela in rhesus macaques infected with CCR5 or CXCR4 utilizing SHIVs
Harouse, JM
Gettie, A
Tan, RCH
Blanchard, J
Cheng-Mayer, C
[J]. SCIENCE, 1999, 284 (5415) : 816 - 819
[7] Dramatic rise in plasma viremia after CD8+ T cell depletion in simian immunodeficiency virus-infected macaques
Jin, X
Bauer, DE
Tuttleton, SE
Lewin, S
Gettie, A
Blanchard, J
Irwin, CE
Safrit, JT
Mittler, J
Weinberger, L
Kostrikis, LG
Zhang, LQ
Perelson, AS
Ho, DD
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (06) : 991 - 998
[8] Potent, protective anti-HIV immune responses generated by bimodal HIV envelope DNA pins protein vaccination
Letvin, NL
Montefiori, DC
Yasutomi, Y
Perry, HC
Davies, ME
Lekutis, C
Alroy, M
Freed, DC
Lord, CI
Handt, LK
Liu, MA
Shiver, JW
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (17) : 9378 - 9383
[9] LIU MA, 1996, VACCINATION MICE NON, V48
[10] Simian immunodeficiency virus DNA vaccine trial in macaques
Lu, S
Arthos, J
Montefiori, DC
Yasutomi, Y
Manson, K
Mustafa, F
Johnson, E
Santoro, JC
Wissink, J
Mullins, JI
Haynes, JR
Letvin, NL
Wyand, M
Robinson, HL
[J]. JOURNAL OF VIROLOGY, 1996, 70 (06) : 3978 - 3991

← 1 2 3 →