Neuromorphological background of cannabis addiction

被引：43

作者：

Wenger, T

Moldrich, G

Furst, S

机构：

[1] Semmelweis Univ, Dept Human Morphol & Dev Biol, Budapest, Hungary

[2] Semmelweis Univ, Dept Pharmacol & Pharmacotherapy, H-1085 Budapest, Hungary

来源：

BRAIN RESEARCH BULLETIN | 2003年 / 61卷 / 02期

关键词：

central cannabinoid receptors; dopamine; immunohistochemistry; rat;

D O I：

10.1016/S0361-9230(03)00081-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The expression of central cannabinoid (CB1) receptors in tyrosine hydroxylase (TH) containing neurones was demonstrated. Co-localisation was present in different brain areas responsible for reward-related mechanisms. The immunohistochemical investigations have shown that co-localisation is present in parts of mesolimbic-mesocortical dopaminergic system like nucleus accumbens (Nacb), ventral tegmental area (VTA), in the striatum, pyriform cortex, respectively. The results suggest a functional role of CB1 receptors in cannabis addiction by acting directly on reward-related structures. (C) 2003 Elsevier Science Inc. All rights reserved.

引用

页码：125 / 128

页数：4

共 23 条

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