Regions of homozygosity and their impact on complex diseases and traits

被引:75
作者
Ku, Chee Seng [1 ]
Naidoo, Nasheen [1 ]
Teo, Shu Mei [1 ]
Pawitan, Yudi [2 ]
机构
[1] Natl Univ Singapore, Yong Loo Lin Sch Med, Ctr Mol Epidemiol, Dept Epidemiol & Publ Hlth, Singapore 117595, Singapore
[2] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
关键词
COPY-NUMBER VARIATION; GENOME-WIDE ASSOCIATION; STRUCTURAL VARIATION; HUMAN-POPULATIONS; COMMON DISEASES; ADULT HEIGHT; FUNCTIONAL IMPLICATIONS; EXTENDED HOMOZYGOSITY; MISSING HERITABILITY; HAPLOTYPE MAP;
D O I
10.1007/s00439-010-0920-6
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Regions of homozygosity (ROHs) are more abundant in the human genome than previously thought. These regions are without heterozygosity, i.e. all the genetic variations within the regions have two identical alleles. At present there are no standardized criteria for defining the ROHs resulting in the different studies using their own criteria in the analysis of homozygosity. Compared to the era of genotyping microsatellite markers, the advent of high-density single nucleotide polymorphism genotyping arrays has provided an unparalleled opportunity to comprehensively detect these regions in the whole genome in different populations. Several studies have identified ROHs which were associated with complex phenotypes such as schizophrenia, late-onset of Alzheimer's disease and height. Collectively, these studies have conclusively shown the abundance of ROHs larger than 1 Mb in outbred populations. The homozygosity association approach holds great promise in identifying genetic susceptibility loci harboring recessive variants for complex diseases and traits.
引用
收藏
页码:1 / 15
页数:15
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