The role of self-peptides in the development of CD4+ CD25+ regulatory T cells

被引：38

作者：

Picca, CC ^{[1
]}

Caton, AJ ^{[1
]}

机构：

[1] Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2005年 / 17卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.coi.2005.01.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The thymus produces a unique lineage of cells known as CD4(+) CD25(+) regulatory T cells, and the exact processes leading to their development continue to be defined. Highly specific interactions between developing thymocytes and cognate self-antigens expressed by radioresistant elements in the thymus have been shown to drive CD4(+) CD25(+) regulatory-T-cell development. The self-peptide(s) that mediate thymic selection of CD4(+) CD25(+) regulatory T cells can also promote their expansion in the periphery, and self-peptides might also play a role in the conversion of CD4(+) CD25(-) T cells into CD25(+) regulatory T cells.

引用

收藏

页码：131 / 136

页数：6

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