Distribution of the hallucinogens N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine in rat brain following intraperitoneal injection:: application of a new solid-phase extraction LC-APcI-MS-MS-isotope dilution method

被引：15

作者：

Barker, SA ^{[1
]}

Littlefield-Chabaud, MA

David, C

机构：

[1] Louisiana State Univ, Sch Vet Med, Dept Physiol Pharmacol & Toxicol, Baton Rouge, LA 70803 USA

[2] Louisiana State Univ, Sch Vet Med, Dept Anat & Cell Biol, Baton Rouge, LA 70803 USA

来源：

JOURNAL OF CHROMATOGRAPHY B | 2001年 / 751卷 / 01期

关键词：

N; N-dimethyltryptamine; 5-methoxy-N;

D O I：

10.1016/S0378-4347(00)00442-4

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A method for the solid-phase extraction (SPE) and liquid chromatographic-atmospheric pressure chemical ionization-mass spectrometric-mass spectrometric-isotope dilution (LC-APcI-MS-MS-ID) analysis of the indole hallucinogens N,N-dimethyltryptamine (DMT) and 5-methoxy DMT (or O-methyl bufotenin, OMB) from rat brain tissue is reported. Rats were administered DMT or OMB by the intraperitoneal route at a dose of 5 mg/kg and sacrificed 15 min post treatment. Brains were dissected into discrete areas and analyzed by the methods described as a demonstration of the procedure's applicability. The synthesis and use of two new deuterated internal standards for these purposes are also reported. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：37 / 47

页数：11

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