GDNF administration induces recovery of the nigrostriatal dopaminergic system both in young and aged parkinsonian mice

被引：46

作者：

Date, I

Aoi, M

Tomita, S

Collins, F

Ohmoto, T

机构：

[1] Okayama Univ, Sch Med, Dept Neurol Surg, Okayama 7008558, Japan

[2] Amgen Inc, Dept Neurosci, Thousand Oaks, CA 91320 USA

来源：

NEUROREPORT | 1998年 / 9卷 / 10期

关键词：

ageing; dopamine; GDNF; Parkinson's disease;

D O I：

10.1097/00001756-199807130-00039

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

GLIAL cell line-derived neurotrophic factor (GDNF) is a member of the transforming growth factor beta superfamily and acts as a neurotrophic factor for the nigrostriatal dopaminergic system. GDNF was injected stereotaxically into the striatum of young (2 months old) and aged (12 months old) C57BL/6 mice that were treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) 1 week earlier. Immunocytochemical and neurochemical analyses showed significant recovery of the nigrostriatal dopaminergic system both in young and in aged mice. Since Parkinson's disease is a neurodegenerative disorder mainly affecting elderly people, this result demonstrates the potential usefulness of GDNF in treating Parkinson's disease. NeuroReport 9: 2365-2369 (C) 1998 Rapid Science Ltd.

引用

页码：2365 / 2369

页数：5

共 32 条

[1] Studies on neuroprotective and regenerative effects of GDNF in a partial lesion model of Parkinson's disease [J].