Carnosine, a protective, anti-ageing peptide?

被引：151

作者：

Hipkiss, AR ^{[1
]}

机构：

[1] Univ London Kings Coll, Mol Biol & Biophys Grp, London WC2R 2LS, England

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 1998年 / 30卷 / 08期

关键词：

D O I：

10.1016/S1357-2725(98)00060-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Carnosine (beta-alanyl-L-histidine) has protective functions additional to anti-oxidant and free-radical scavenging roles. It extends cultured human fibroblast life-span, kills transformed cells, protects cells against aldehydes and an amyloid peptide fragment and inhibits, in vitro, protein glycation (formation of cross-links, carbonyl groups and AGEs) and DNA/protein cross-linking. Carnosine is an aldehyde scavenger, a likely lipofuscin (age pigment) precursor and possible modulator of diabetic complications, atherosclerosis and Alzheimer's disease. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：863 / 868

页数：6

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