Rotavirus encephalopathy: Pathogenesis reviewed

被引：56

作者：

Goldwater, PN ^{[1
]}

Rowland, K

Power, R

Thesinger, M

Abbott, K

Grieve, A

Palombo, EA

Masendycz, PJ

Wilkinson, I

Bear, J

机构：

[1] Womens & Childrens Hosp, Dept Microbiol & Infect Dis, N Adelaide, SA 5006, Australia

[2] Lyell McEwin Hlth Serv, Elizabeth, SA, Australia

[3] Royal Childrens Hosp, Dept Gastroenterol & Clin Nutr, Natl Rotavirus Reference Ctr, Parkville, Vic 3052, Australia

[4] John Hunter Hosp, Newcastle, NSW, Australia

[5] John Hunter Childrens Hosp, Newcastle, NSW, Australia

来源：

JOURNAL OF PAEDIATRICS AND CHILD HEALTH | 2001年 / 37卷 / 02期

关键词：

central nervous system infection; pathogenesis; rotavirus;

D O I：

10.1046/j.1440-1754.2001.00596.x

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Two cases of rotavirus gastroenteritis associated with neurological involvement, one with encephalitis (defined by abnormal neurological signs, cerebrospinal fluid (CSF) pleocytosis and detection of rotavirus genomic nucleic acid in the CSF) and one with a non-inflammatory encephalopathy (defined by abnormal neurological signs, an entirely normal CSF and detection of rotavirus genomic nucleic acid in the CSF), are presented and used as a basis to review and explore potential pathogenetic mechanisms, including direct viral replication within neurons and indirect effects of the newly described rotavirus 'enterotoxin'.

引用

页码：206 / 209

页数：4

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