Nephrotic syndrome after allogeneic hematopoietic stem cell transplantation: etiology and pathogenesis

被引：22

作者：

Luo, Xiao-dan ^{[1
]}

Liu, Qi-fa ^{[1
]}

Zhang, Yu ^{[1
]}

Sun, Jing ^{[1
]}

Wang, Guo-bao ^{[1
]}

Fan, Zhi-ping ^{[1
]}

Yi, Zheng-shan ^{[1
]}

Ling, Yi-wen ^{[1
]}

Wei, Yong-qiang ^{[1
]}

Liu, Xiao-li ^{[1
]}

Xu, Bing ^{[1
]}

机构：

[1] So Med Univ, Nanfang Hosp, Dept Hematol, Guangzhou 510515, Guangdong, Peoples R China

来源：

BLOOD CELLS MOLECULES AND DISEASES | 2011年 / 46卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Nephrotic syndrome; Cytokine; Tregs; Allogeneic hematopoietic stem cell transplantation; REGULATORY T-CELLS; MEMBRANOUS NEPHROPATHY; DISEASE; ALPHA;

D O I：

10.1016/j.bcmd.2010.12.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In this study we investigated the etiology and pathogenesis of nephrotic syndrome (NS) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) in 257 patients with hematopoietic malignancies who survived more than 2 months post allo-HSCT. Associations of NS with the conditioning regimen, graft versus host disease (GVHD), and other variables were analyzed. Pathologic features of the kidney, regulatory T cells (Tregs), interferon-gamma (IFN-gamma), and tumor necrosis factor-alpha (TNF-alpha) were studied. NS was identified in 9 patients. The number of Tregs at day + 30, 60, 90, and 180 was lower in NS patients than non-NS patients (P=0.001, 0.001, 0.007, 0.003). Serum levels of IFN-gamma and TNF-alpha were higher in NS patients (P=0.032, 0.001, respectively). NS post allo-HSCT was associated with the occurrence of chronic GVHD (P=0.02). NS post-HSCT is an immune disorder that may involve immune complex deposition, Th1 cytokines, and Tregs. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：182 / 187

页数：6

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