Effect of octreotide on gastrointestinal motility in children with functional gastrointestinal symptoms

被引:25
作者
Di Lorenzo, C
Lucanto, C
Flores, AF
Idries, S
Hyman, PE
机构
[1] Univ Pittsburgh, Childrens Hosp Pittsburgh, Dept Pediat, Pittsburgh, PA 15213 USA
[2] Newton Wellesley Hosp, Newton, MA USA
[3] Childrens Hosp Orange Cty, Orange, CA 92668 USA
关键词
functional bowel disorders; gastrointestinal motility; motor migrating complex; octreotide;
D O I
10.1097/00005176-199811000-00002
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background: The somatostatin analogue octreotide has been proposed as a possible therapeutic agent in patients with abnormal gastrointestinal motility. This study was conducted to study the effects of 0.5 mu g/kg and 1.0 mu g/kg subcutaneous octreotide on antroduodenal motility in children with chronic gastrointestinal disorders. Methods: Twenty-three children were studied, eight with intestinal pseudo-obstruction, six with nonulcer dyspepsia, six with gastroesophageal reflux disease, and three with intractable constipation. After recording fasting motility for more than 4 hours, the children were randomized to receive 0.5 mu g/kg or 1 mu g/kg of subcutaneous octreotide. Motility was recorded for another hour after feeding in 12 children. Results: Phase III of the motor migrating complex was present in 13 of 23 children before and in 21 after octreotide (p < 0.02). All phase III episodes after administration of octreotide except one originated in the small intestine. Phase IIIs after octreotide were longer and were propagated faster than the spontaneous phase IIIs. There were no antral contractions during fasting after octreotide. There was a significant decrease in phase II intestinal motor activity in the hour after administration of octreotide (p < 0.001). There was no difference in effect between the two doses. After feeding, antral contractions were present in all children, and intestinal phase ms were not abolished. Conclusions: In children with chronic bowel disorders, subcutaneous octreotide induced phase ms that differed from spontaneous phase IIIs and were not inhibited by meals. Octreotide decreased antral motility during Tasting and inhibited intestinal phase II. Feeding abolished the inhibitory effect of octreotide on antral motility.
引用
收藏
页码:508 / 512
页数:5
相关论文
共 31 条
[1]   INTESTINAL MOTILITY AND JEJUNAL FEEDING IN CHILDREN WITH CHRONIC INTESTINAL PSEUDOOBSTRUCTION [J].
DILORENZO, C ;
FLORES, AF ;
BUIE, T ;
HYMAN, PE .
GASTROENTEROLOGY, 1995, 108 (05) :1379-1385
[2]  
DILORENZO C, 1994, SCAND J GASTROENTERO, V29, P799
[3]   VARIABILITY OF MIGRATING MOTOR COMPLEX IN HUMANS [J].
DOOLEY, CP ;
DILORENZO, C ;
VALENZUELA, JE .
DIGESTIVE DISEASES AND SCIENCES, 1992, 37 (05) :723-728
[4]  
FOXTHRELKELD JET, 1993, ILLUSTRATED GUIDE GA, P78
[5]   EFFECT OF A LONG-ACTING SOMATOSTATIN ANALOG (SMS 201-995) ON POSTPRANDIAL GASTRIC-EMPTYING OF TC-99M-TIN COLLOID AND MOUTH-TO-CECUM TRANSIT-TIME IN MAN [J].
FUESSL, HS ;
CAROLAN, G ;
WILLIAMS, G ;
BLOOM, SR .
DIGESTION, 1987, 36 (02) :101-107
[6]   ACTIONS OF SOMATOSTATINS ON GASTRIC SMOOTH-MUSCLE CELLS [J].
GU, ZF ;
PRADHAN, T ;
COY, DH ;
MANTEY, S ;
BUNNETT, NW ;
JENSEN, RT ;
MATON, PN .
AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 262 (03) :G432-G438
[7]   PHARMACODYNAMIC EFFECTS OF SANDOSTATIN(R) IN THE GASTROINTESTINAL-TRACT [J].
GYR, KE ;
MEIER, R .
DIGESTION, 1993, 54 :14-19
[8]   EFFECT OF OCTREOTIDE ON GASTROINTESTINAL PRESSURE PROFILES IN HEALTH AND IN FUNCTIONAL AND ORGANIC GASTROINTESTINAL DISORDERS [J].
HARUMA, K ;
WISTE, JA ;
CAMILLERI, M .
GUT, 1994, 35 (08) :1064-1069
[9]  
HOSTEIN J, 1984, GASTROENTEROLOGY, V87, P1004
[10]   Roles of gall bladder emptying and intestinal transit in the pathogenesis of octreotide induced gall bladder stones [J].
Hussaini, SH ;
Pereira, SP ;
Veysey, MJ ;
Kennedy, C ;
Jenkins, P ;
Murphy, GM ;
Wass, JAH ;
Dowling, RH .
GUT, 1996, 38 (05) :775-783