Simultaneous elevation of the levels of circulating monocyte chemoattractant protein-1 and tissue factor in acute coronary syndromes

被引：44

作者：

Nishiyama, K

Ogawa, H

Yasue, H

Soejima, H

Misumi, K

Takazoe, K

Yoshimura, M

Kugiyama, K

Tsuji, I

Kumeda, K

机构：

[1] Kumamoto Univ, Sch Med, Div Cardiol, Kumamoto 8608556, Japan

[2] Chemo Sero Therapeut Res Inst, Kumamoto, Japan

来源：

JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION | 1998年 / 62卷 / 09期

关键词：

acute coronary syndromes; monocyte chemoattractant protein-1; tissue factor;

D O I：

10.1253/jcj.62.710

中图分类号：

N09 [自然科学史]; B [哲学、宗教];

学科分类号：

01 ; 0101 ; 010108 ; 060207 ; 060305 ; 0712 ;

摘要：

The levels of circulating monocyte chemoattractant protein-1 (MCP-I) and tissue factor (TF) were examined on admission in 46 consecutive patients with acute coronary syndromes (ACS) and 30 patients with stable exertional angina (SEA). The plasma levels of both MCP-1 and TF were higher in the ACS patients than in the SEA patients (MCP-1: p<0.001; TF: p<0.001). Only the circulating TF level related to the number of diseased vessels. A positive correlation between plasma MCP-I and TF levels was found (r=0.476, p<0.001). These results suggest that circulating MCP-1 plays an important role in the pathogenesis and/or development of ACS.

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收藏

页码：710 / 712

页数：3

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