The role of apoptosis in regulating hematopoiesis and hematopoietic stem cells

被引：42

作者：

Domen, J ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Med, Div Med Oncol & Transplantat, Durham, NC 27710 USA

来源：

IMMUNOLOGIC RESEARCH | 2000年 / 22卷 / 2-3期

关键词：

apoptosis; Bcl-2; hematopoietic stem cell; radiation; caspase;

D O I：

10.1385/IR:22:2-3:83

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Apoptosis, or the ability of cells to die in an orderly and highly regulated manner, is essential for normal development and homeostasis of multicellular organisms. Diseases in which deregulation of this process is implicated include autoimmune diseases, cancer and Alzheimer's disease, The importance of apoptosis for the development and function of lymphoid cells has been extensively investigated. Less clear is the role apoptosis plays in regulating early progenitor and stem cell compartments. This question is being investigated using a transgenic mouse model, H2K-BCL-2, in which all hematopoietic cells have an increased resistance to apoptosis. The same transgenic model is also being used to address the question whether protection against apoptosis can increase system-wide resistance to lethal challenges such as irradiation and chemotherapeutic agents.

引用

页码：83 / 94

页数：12

共 92 条

[1] Bcl2 reduces lymphomagenesis in Delta V-TCR beta transgenic mice [J].

Acton, D ;

Jacobs, H ;

Domen, J ;

Berns, A .

ONCOGENE, 1997, 14 (21) :2497-2501

[2] The Bcl-2 protein family: Arbiters of cell survival [J].

Adams, JM ;

Cory, S .

SCIENCE, 1998, 281 (5381) :1322-1326

[3] Hematopoietic stem cells are not direct cytotoxic targets of natural killer cells [J].

Aguila, HL ;

Weissman, IL .

BLOOD, 1996, 87 (04) :1225-1231

[4] A clonogenic common myeloid progenitor that gives rise to all myeloid lineages [J].

Akashi, K ;

Traver, D ;

Miyamoto, T ;

Weissman, IL .

NATURE, 2000, 404 (6774) :193-197

[5] The Bcl-2 protein family [J].

Antonsson, B ;

Martinou, JC .

EXPERIMENTAL CELL RESEARCH, 2000, 256 (01) :50-57

[6] Apoptosis control by death and decoy receptors [J].

Ashkenazi, A ;

Dixit, VM .

CURRENT OPINION IN CELL BIOLOGY, 1999, 11 (02) :255-260

[7] Death receptors: Signaling and modulation [J].

Ashkenazi, A ;

Dixit, VM .

SCIENCE, 1998, 281 (5381) :1305-1308

[8] CLONING THE CHROMOSOMAL BREAKPOINT OF T(14-18) HUMAN LYMPHOMAS - CLUSTERING AROUND JH ON CHROMOSOME-14 AND NEAR A TRANSCRIPTIONAL UNIT ON 18 [J].

BAKHSHI, A ;

JENSEN, JP ;

GOLDMAN, P ;

WRIGHT, JJ ;

MCBRIDE, OW ;

EPSTEIN, AL ;

KORSMEYER, SJ .

CELL, 1985, 41 (03) :899-906

[9] Expression of Fas/CD95 and Bcl-2 by primitive hematopoietic progenitors freshly isolated from human fetal liver [J].

Barcena, A ;

Park, SW ;

Banapour, B ;

Muench, MO ;

Mechetner, E .

BLOOD, 1996, 88 (06) :2013-2025

[10] Apoptosis without caspases: an inefficient molecular guillotine? [J].

Borner, C ;

Monney, L .

CELL DEATH AND DIFFERENTIATION, 1999, 6 (06) :497-507

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