Ceramides modulate programmed cell death in plants

被引：299

作者：

Liang, H ^{[1
]}

Yao, N ^{[1
]}

Song, LT ^{[1
]}

Luo, S ^{[1
]}

Lu, H ^{[1
]}

Greenberg, LT ^{[1
]}

机构：

[1] Univ Chicago, Dept Mol Genet & Cell Biol, Chicago, IL 60637 USA

来源：

GENES & DEVELOPMENT | 2003年 / 17卷 / 21期

关键词：

apoptosis; sphingolipids; Arabidopsis; ceramide kinase;

D O I：

10.1101/gad.1140503

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The balance between the bioactive sphingolipid ceramide and its phosphorylated derivative has been proposed to modulate the amount of programmed cell death (PCD) in eukaryotes. We characterized the first ceramide kinase (CERK) mutant in any organism. The Arabidopsis CERK mutant, called accelerated cell death 5, accumulates CERK substrates and shows enhanced disease symptoms during pathogen attack and apoptotic-like cell death dependent on defense signaling late in development. ACD5 protein shows high specificity for ceramides in vitro. Strikingly, C2 ceramide induces, whereas its phosphorylated derivative partially blocks, plant PCD, supporting a role for ceramide phosphorylation in modulating cell death in plants.

引用

页码：2636 / 2641

页数：6

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