α-tocopherol controls cell proliferation in the adult rat dentate gyrus

被引：12

作者：

Cuppini, R

Ciaroni, S

Cecchini, T

Ambrogini, P

Ferri, P

Del Grande, P

Papa, S

机构：

[1] Univ Urbino, Inst Physiol Sci, I-61029 Urbino, PS, Italy

[2] Univ Urbino, Inst Morphol Sci, I-61029 Urbino, PS, Italy

来源：

NEUROSCIENCE LETTERS | 2001年 / 303卷 / 03期

关键词：

alpha-tocopherol; 5-bromo-2 '-deoxyuridine; cell proliferation; cell death; dentate gyrus;

D O I：

10.1016/S0304-3940(01)01747-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of alpha -tocopherol on cell proliferation and proliferated cell survival was investigated in the dentate gyrus of adult rats. Adult rats were supplemented with alpha -tocopherol, injected with 5-bromo-2'-deoxyuridine (BrdU), that is incorporated into DNA during the S-phase, and killed at different time after BrdU injection. The number of newborn cells decreased after alpha -tocopherol supplementation, confirming the hypothesis that alpha -tocopherol is able to depress cell proliferation in vivo. Most newborn cells die within few days; more newborn cells survive in alpha -tocopherol-treated rats, suggesting the hypothesis that alpha -tocopherol decreases cell death. (C) 2001 Published by Elsevier Science Ireland Ltd.

引用

页码：198 / 200

页数：3

共 21 条

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